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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Daniel Tague | 153 | 690 | 1950 | |
| 2. | Sean Hawk | 144 | 693 | 1948 | |
| 3. | Alvin Chao | 140 | 759 | 1950 | |
| 4. | Todd Ryerson | 137 | 682 | 1948 | |
| 5. | Alonzo Zendejas | 136 | 678 | 1948 | |
| 6. | Sean Hawk | 134 | 689 | 1949 | |
| Darrell Recinos | 134 | 652 | 1949 | ||
| 8. | Vernon Potter | 133 | 648 | 1947 | |
| Raymond Forster | 133 | 628 | 1947 | ||
| 10. | Sabas Reyes | 132 | 552 | 1950 | |
| 11. | Paul Warrior | 130 | 654 | 1950 | |
| Raymond Forster | 130 | 625 | 1950 | ||
| 13. | Phillip Brun | 129 | 605 | 1949 | |
| Steven Butler | 129 | 600 | 1949 | ||
| Sean Hawk | 129 | 673 | 1947 | ||
| 16. | Victor Bruch | 128 | 725 | 1950 | |
| Alonzo Zendejas | 128 | 703 | 1950 | ||
| 18. | Victor Bruch | 127 | 649 | 1947 | |
| William Britt | 127 | 630 | 1947 | ||
| 20. | Darrell Recinos | 125 | 592 | 1948 | |
| 21. | Theron Klos | 124 | 632 | 1950 | |
| David Bachand | 124 | 532 | 1950 | ||
| Raymond Forster | 124 | 629 | 1948 | ||
| Larry Gober | 124 | 626 | 1947 | ||
| 25. | Todd Ryerson | 123 | 653 | 1950 | |
| Alonzo Zendejas | 123 | 658 | 1949 | ||
| Daniel Tague | 123 | 647 | 1949 | ||
| Paul South | 123 | 579 | 1949 | ||
| Alonzo Zendejas | 123 | 674 | 1947 | ||
| 30. | Vernon Potter | 122 | 629 | 1950 | |
| Vernon Potter | 122 | 589 | 1948 | ||
| 32. | Herbert Slagle | 121 | 700 | 1949 | |
| Alexander Stuber | 121 | 584 | 1947 | ||
| 34. | Theron Klos | 120 | 588 | 1948 | |
| 35. | Jason Blankenship | 119 | 629 | 1950 | |
| Paul South | 119 | 564 | 1950 | ||
| William Britt | 119 | 553 | 1950 | ||
| 38. | Raymond Forster | 118 | 591 | 1949 | |
| 39. | Thomas Moncada | 117 | 746 | 1950 | |
| Herbert Slagle | 117 | 687 | 1950 | ||
| Santiago Rodriguez | 117 | 668 | 1950 | ||
| Robert Vanetten | 117 | 699 | 1949 | ||
| 43. | Darrell Recinos | 116 | 624 | 1950 | |
| 44. | Todd Ryerson | 115 | 587 | 1949 | |
| William Britt | 115 | 647 | 1948 | ||
| 46. | Vernon Potter | 114 | 567 | 1949 | |
| Pedro Echeveste | 114 | 612 | 1947 | ||
| 48. | Sean Hawk | 113 | 584 | 1950 | |
| 49. | Russell Christman | 112 | 673 | 1950 | |
| Maurice Jamar | 112 | 567 | 1948 | ||
| Leroy Hibner | 112 | 511 | 1948 | ||
| Darrell Recinos | 112 | 554 | 1947 | ||
| 53. | Santiago Rodriguez | 111 | 633 | 1949 | |
| William Lincoln | 111 | 551 | 1949 | ||
| Neil Williams | 111 | 738 | 1948 | ||
| 56. | Steven Butler | 110 | 557 | 1950 | |
| Shawn Deluna | 110 | 700 | 1949 | ||
| Victor Bruch | 110 | 596 | 1948 | ||
| 59. | Pedro Echeveste | 109 | 688 | 1950 | |
| Thomas Moncada | 109 | 658 | 1947 | ||
| 61. | Leonard Cortines | 108 | 654 | 1949 | |
| Theron Klos | 108 | 615 | 1949 | ||
| Daniel Tague | 108 | 561 | 1948 | ||
| 64. | Jerry Fender | 107 | 667 | 1949 | |
| Pedro Echeveste | 107 | 659 | 1949 | ||
| Philip Stehle | 107 | 639 | 1947 | ||
| Michael Bufford | 107 | 544 | 1947 | ||
| 68. | Thomas Moncada | 106 | 697 | 1949 | |
| Paul Warrior | 106 | 623 | 1948 | ||
| Arthur Wade | 106 | 732 | 1947 | ||
| 71. | James Schreffler | 105 | 600 | 1950 | |
| Edmundo Rubio | 105 | 606 | 1949 | ||
| Samuel Blades | 105 | 672 | 1948 | ||
| Bobby Stutz | 105 | 619 | 1948 | ||
| Fede Medina | 105 | 559 | 1948 | ||
| Theron Klos | 105 | 573 | 1947 | ||
| 77. | William Giesen | 104 | 522 | 1949 | |
| Todd Ryerson | 104 | 669 | 1947 | ||
| John Welch | 104 | 632 | 1947 | ||
| 80. | Neil Williams | 103 | 691 | 1949 | |
| Dave Romeo | 103 | 684 | 1948 | ||
| Steven Butler | 103 | 510 | 1948 | ||
| 83. | Victor Bruch | 102 | 650 | 1949 | |
| Roberto Fraile | 102 | 605 | 1947 | ||
| 85. | Stephen Carr | 101 | 672 | 1950 | |
| Jerry Fender | 101 | 663 | 1950 | ||
| Phillip Brun | 101 | 473 | 1950 | ||
| Michael Fraser | 101 | 527 | 1949 | ||
| Shawn Deluna | 101 | 723 | 1948 | ||
| 90. | Richard Lind | 100 | 677 | 1948 | |
| Shawn Deluna | 100 | 703 | 1947 | ||
| Loren Trull | 100 | 638 | 1947 | ||
| Alberto Vela | 100 | 524 | 1947 | ||
| 94. | James Bristow | 99 | 695 | 1950 | |
| Michael Bufford | 99 | 575 | 1950 | ||
| Jose Carbonell | 99 | 659 | 1947 | ||
| Craig Allen | 99 | 473 | 1947 | ||
| 98. | Peter Wyatt | 98 | 679 | 1950 | |
| Duane Lara | 98 | 676 | 1950 | ||
| John Edmiston | 98 | 608 | 1950 |
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