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| Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Sean Hawk | 520 | 2639 | 1947-1950 | |
| 2. | Alonzo Zendejas | 510 | 2713 | 1947-1950 | |
| 3. | Raymond Forster | 505 | 2473 | 1947-1950 | |
| 4. | Vernon Potter | 491 | 2433 | 1947-1950 | |
| 5. | Darrell Recinos | 487 | 2422 | 1947-1950 | |
| 6. | Todd Ryerson | 479 | 2591 | 1947-1950 | |
| 7. | Victor Bruch | 467 | 2620 | 1947-1950 | |
| 8. | Theron Klos | 457 | 2408 | 1947-1950 | |
| 9. | William Britt | 456 | 2328 | 1947-1950 | |
| 10. | Daniel Tague | 437 | 2186 | 1947-1950 | |
| 11. | Thomas Moncada | 412 | 2708 | 1947-1950 | |
| 12. | Pedro Echeveste | 407 | 2513 | 1947-1950 | |
| 13. | Shawn Deluna | 403 | 2844 | 1947-1950 | |
| 14. | Jerry Fender | 392 | 2647 | 1947-1950 | |
| Edmundo Rubio | 392 | 2546 | 1947-1950 | ||
| 16. | Michael Bufford | 383 | 2246 | 1947-1950 | |
| 17. | Matthew Thompson | 381 | 2428 | 1947-1950 | |
| 18. | Russell Christman | 369 | 2626 | 1947-1950 | |
| 19. | Bobby Stutz | 367 | 2110 | 1947-1950 | |
| 20. | Loren Trull | 366 | 2614 | 1947-1950 | |
| 21. | John Welch | 362 | 2409 | 1947-1950 | |
| Ernest Orlandi | 362 | 2326 | 1947-1950 | ||
| Santiago Rodriguez | 362 | 1903 | 1947-1950 | ||
| 24. | Duane Lara | 357 | 2662 | 1947-1950 | |
| 25. | Craig Allen | 356 | 1987 | 1947-1950 | |
| 26. | Arthur Wade | 353 | 2835 | 1947-1950 | |
| Paul Warrior | 353 | 2087 | 1947-1950 | ||
| 28. | Jose Carbonell | 352 | 2610 | 1947-1950 | |
| Cesar Olivera | 352 | 2609 | 1947-1950 | ||
| 30. | Gary Tawney | 349 | 2406 | 1947-1950 | |
| 31. | Peter Wyatt | 346 | 2737 | 1947-1950 | |
| 32. | Phillip Brun | 345 | 1710 | 1947-1950 | |
| 33. | Eric Salas | 343 | 2584 | 1947-1950 | |
| 34. | Steven Butler | 342 | 1667 | 1948-1950 | |
| 35. | Alonso Guglielmo | 341 | 2597 | 1947-1950 | |
| 36. | Alan Nelson | 339 | 2407 | 1947-1950 | |
| 37. | William Lincoln | 329 | 1945 | 1947-1950 | |
| 38. | Philip Stehle | 328 | 2150 | 1947-1950 | |
| 39. | Herbert Slagle | 325 | 1973 | 1948-1950 | |
| 40. | Sabas Reyes | 321 | 2312 | 1947-1950 | |
| 41. | Norman Oconnor | 318 | 1622 | 1947-1950 | |
| 42. | John Swofford | 315 | 2226 | 1947-1950 | |
| 43. | Leon Rebello | 314 | 2698 | 1947-1950 | |
| 44. | Douglas Corp | 310 | 2781 | 1947-1950 | |
| 45. | Glen Ferguson | 309 | 2692 | 1947-1950 | |
| 46. | Christopher Hiltner | 307 | 2767 | 1947-1950 | |
| 47. | George Busby | 306 | 2704 | 1947-1950 | |
| 48. | Daniel Woods | 304 | 2626 | 1947-1950 | |
| 49. | Howard Goldston | 303 | 2129 | 1947-1950 | |
| 50. | Herman Eberle | 301 | 2753 | 1947-1950 | |
| Jacky Baeza | 301 | 2690 | 1947-1950 | ||
| 52. | Kelley Ferland | 299 | 2645 | 1947-1950 | |
| Maurice Jamar | 299 | 1550 | 1947-1950 | ||
| 54. | Joseph Rosado | 296 | 2667 | 1947-1950 | |
| Michael Duncanson | 296 | 2402 | 1947-1950 | ||
| 56. | William Barnwell | 288 | 2197 | 1947-1950 | |
| 57. | Paul Norris | 287 | 2665 | 1947-1950 | |
| 58. | Luis Rosenblatt | 285 | 2677 | 1947-1950 | |
| Joel Turnage | 285 | 1928 | 1947-1950 | ||
| 60. | Mark Browne | 284 | 2577 | 1947-1950 | |
| Steven Nickelson | 284 | 2523 | 1947-1950 | ||
| 62. | Rafael Naranjo | 283 | 2721 | 1947-1950 | |
| 63. | Alejo Armijo | 282 | 2315 | 1947-1950 | |
| Lloyd Wall | 282 | 2072 | 1947-1950 | ||
| Alberto Vela | 282 | 1689 | 1947-1950 | ||
| 66. | Michael Ippolito | 281 | 2325 | 1947-1950 | |
| Gerald McClaskey | 281 | 2185 | 1947-1950 | ||
| 68. | Daniel Armstead | 278 | 2621 | 1947-1950 | |
| 69. | Nathan Knighten | 277 | 2640 | 1947-1950 | |
| 70. | Michael Fraser | 275 | 1415 | 1947-1949 | |
| 71. | Jose Sanchez | 271 | 2584 | 1947-1950 | |
| Marshall Searles | 271 | 2345 | 1947-1950 | ||
| Dave Romeo | 271 | 1844 | 1947-1949 | ||
| 74. | Paul Haga | 270 | 2751 | 1947-1950 | |
| Alberto Castro | 270 | 2157 | 1947-1950 | ||
| 76. | John To | 269 | 2685 | 1947-1950 | |
| 77. | Leonard Cortines | 265 | 1957 | 1947-1949 | |
| 78. | Reuben Maddocks | 264 | 2639 | 1947-1950 | |
| 79. | Max Acuņa | 262 | 2480 | 1947-1950 | |
| 80. | Neil Williams | 261 | 1755 | 1947-1949 | |
| 81. | Allan Dickerson | 258 | 2518 | 1947-1950 | |
| 82. | Wesley Bilderback | 257 | 2231 | 1947-1950 | |
| 83. | Jesus Vivas | 256 | 2170 | 1947-1950 | |
| 84. | Trevor Maury | 248 | 1961 | 1947-1950 | |
| 85. | Richard Raynor | 246 | 2254 | 1947-1950 | |
| 86. | Bill Marquardt | 244 | 2183 | 1947-1950 | |
| 87. | Joel Oliveira | 242 | 2270 | 1947-1950 | |
| Paul South | 242 | 1143 | 1949-1950 | ||
| 89. | William Giesen | 241 | 1591 | 1947-1950 | |
| 90. | James Schreffler | 239 | 1375 | 1947-1950 | |
| 91. | Wiley Adkins | 237 | 2606 | 1947-1950 | |
| James Bristow | 237 | 1608 | 1947-1950 | ||
| 93. | John Patterson | 236 | 2409 | 1947-1950 | |
| Berny Romero | 236 | 1980 | 1947-1950 | ||
| 95. | Luis Caņaveral | 235 | 2613 | 1947-1950 | |
| Guy Mickelson | 235 | 2567 | 1947-1950 | ||
| Danny Saravia | 235 | 2263 | 1947-1950 | ||
| 98. | Mark Woodby | 230 | 1612 | 1947-1949 | |
| 99. | Tory Dalessandro | 229 | 1550 | 1947-1950 | |
| 100. | Sebastian Moreno | 228 | 1598 | 1947-1950 |
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